Chimbira T H, Anderson A B, Cope E, Turnbull A C
Br J Obstet Gynaecol. 1980 Apr;87(4):330-6. doi: 10.1111/j.1471-0528.1980.tb04550.x.
In 13 ovulatory women with objective evidence of menorrhagia (menstrual blood loss greater than 80 ml), danazol 400 mg given daily for 12 weeks suppressed ovulation as shown by absence of gonadotrophin peaks, low serum progesterone levels and flat basal body temperature recordings. Serum concentrations of luteinising hormone and follicle stimulating hormone were within the range found during the normal menstrual cycle but oestradiol concentrations tended to fall, reaching levels less than 100 pmol/l in some patients. Danazol treatment had no effect on levels of androstenedione or dehydroepiandrosterone and its sulphate. The presence or absence of cyclical bleeding on treatment, and the measured blood loss was unrelated to circulating oestradiol levels.
在13名有月经过多客观证据（月经失血超过80毫升）的排卵女性中，每日给予400毫克达那唑，持续12周，结果显示，促性腺激素峰值消失、血清孕酮水平降低以及基础体温记录呈平稳状态，表明排卵受到抑制。促黄体生成素和促卵泡生成素的血清浓度在正常月经周期范围内，但雌二醇浓度趋于下降，部分患者降至低于100皮摩尔/升的水平。达那唑治疗对雄烯二酮或脱氢表雄酮及其硫酸盐水平没有影响。治疗期间是否出现周期性出血以及测得的失血量与循环雌二醇水平无关。
