达那唑与炔诺酮治疗以月经过多为表现的功能失调性子宫出血的对比研究。
A comparative study of danazol and norethisterone in dysfunctional uterine bleeding presenting as menorrhagia.
作者信息
Bonduelle M, Walker J J, Calder A A
机构信息
Department of Obstetrics and Gynaecology, Glasgow Royal Infirmary, UK.
出版信息
Postgrad Med J. 1991 Sep;67(791):833-6. doi: 10.1136/pgmj.67.791.833.
This randomized open study compared the efficacy and safety of norethisterone, 5 mg three times a day from day 19 to 26, and danazol, 200 mg daily, in the treatment of dysfunctional uterine bleeding presenting as menorrhagia. Clinical criteria were employed to confirm the diagnosis, and subjective assessment of the condition was performed during one pre-treatment and three treatment cycles. Fourteen patients commenced norethisterone and 10 danazol. Bleeding intensity scores were significantly lower with danazol than with norethisterone, and patients assessed their blood loss to be significantly less with danazol than with norethisterone. Associated symptoms of backache and abdominal pain were improved to a similar degree by both treatments. Adverse reactions were reported with similar frequency and were of a similar nature in both treatment groups.
这项随机开放研究比较了炔诺酮（从第19天至26天每天三次，每次5毫克）和达那唑（每日200毫克）治疗表现为月经过多的功能失调性子宫出血的疗效和安全性。采用临床标准确诊，并在一个治疗前周期和三个治疗周期内对病情进行主观评估。14例患者开始服用炔诺酮，10例患者开始服用达那唑。达那唑组的出血强度评分显著低于炔诺酮组，患者评估其服用达那唑时的失血量明显少于服用炔诺酮时。两种治疗方法对背痛和腹痛等相关症状的改善程度相似。两个治疗组报告的不良反应频率相似，性质也相似。
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