Carlström K, Lindberg B S
Br J Obstet Gynaecol. 1980 Jul;87(7):590-6.
Plasma levels of unconjugated and total oestriol and urinary excretion of oestriol were measured in ten healthy women with uncomplicated pregnancy and with normal renal function. A significant correlation between plasma total oestriol and urinary oestriol was found in five out of ten patients and between plasma total and unconjugated oestriol in only four of ten patients. When the data from the ten patients were combined there were significant correlations between urinary oestriol and the two plasma oestriol species as well as between plasma unconjugated and total oestriol. The mean urinary oestriol excretion correlated significantly with the mean urine volume. No significant correlation was found in the individual subjects between oestriol clearance and creatinine clearance, but the combined data from the ten patients yielded a highly significant correlation. The differences within or between days was highest for plasma unconjugated oestriol and lowest for urinary oestriol/mmol of creatinine. Over a three to four day period, a drop of 20 per cent in urinary oestriol/mmol of creatinine, 25 per cent in urinary oestriol/24 hours, 35 percent in plasma total oestriol and 40 per cent in plasma unconjugated oestriol do not necessarily indicate fetal danger.
对10名妊娠情况正常且肾功能正常的健康女性，测定了其血浆中未结合雌三醇和总雌三醇的水平以及雌三醇的尿排泄量。10名患者中有5名患者血浆总雌三醇与尿雌三醇之间存在显著相关性，10名患者中只有4名患者血浆总雌三醇与未结合雌三醇之间存在显著相关性。当将10名患者的数据合并时，尿雌三醇与两种血浆雌三醇种类之间以及血浆未结合雌三醇与总雌三醇之间存在显著相关性。尿雌三醇平均排泄量与平均尿量显著相关。个体受试者中雌三醇清除率与肌酐清除率之间未发现显著相关性，但10名患者的合并数据显示出高度显著的相关性。血浆未结合雌三醇在日内或日间的差异最大，而尿雌三醇/每毫摩尔肌酐的差异最小。在三到四天的时间内，尿雌三醇/每毫摩尔肌酐下降20%、尿雌三醇/24小时下降25%、血浆总雌三醇下降35%以及血浆未结合雌三醇下降40%，并不一定表明存在胎儿危险。
