[左旋咪唑对单核吞噬系统细胞的作用机制]
[Mechanism of action of levamisole on cells of the mononuclear phagocytizing system].
作者信息
Favorskaia Iu N, Zaĭtseva L G, Shliakhov E N, Kiku V F, Buracheva S A
出版信息
Biull Eksp Biol Med. 1980 Oct;90(10):456-8.
PMID:7426709
Abstract
The levamisole effect on the phagocytic capacity of macrophages and their membrane permeability was studied in A and CBA mice. It was shown that both in vivo and in vitro, levamisole treatment of peritoneal and splenic macrophages resulted in the diminution of antigen uptake and slowing down of its clearance as compared with control animals. The exposure to levamisole led to the enhanced membrane permeability and the decreased total cathepsin activity in the peritoneal cells and in their lysosomes.
摘要
在A系和CBA系小鼠中研究了左旋咪唑对巨噬细胞吞噬能力及其膜通透性的影响。结果表明，与对照动物相比，无论在体内还是体外，用左旋咪唑处理腹膜和脾脏巨噬细胞均导致抗原摄取减少及其清除减慢。暴露于左旋咪唑会导致腹膜细胞及其溶酶体的膜通透性增强和组织蛋白酶总活性降低。
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