Timofeeva O A
Biull Eksp Biol Med. 1980 Sep;90(9):289-91.
In freely moving rats, a chronic focus of excitation was created in the initiative centers of food motivation by longterm subthreshold electric stimulation of the lateral hypothalamus (LH). This stimulation resulted in a progressive formation of a syndrome reinforced by food motivation, which was manifested in a significant increase in the number of food motivation instrumental reactions and in putting on weight. Concurrently the rabbits demonstrated an intensification of the orienting-investigative behavior and general locomotor activity. The syndrome induced was not strongly connected with the beginning of the electric stimulation and persisted without weakening for a long time (2--4 weeks) after chronic electric stimulation was discontinued. By the character of development, manifestations and persistence the syndrome overtly differed from other phenomena of hyperphagia which were obtained by other workers during chronic electric stimulation of LH. It is assumed that at the basis of the syndrome there lies a formaton of a longterm generator of excitation in the "pacemaker" of food motivation.
在自由活动的大鼠中，通过对下丘脑外侧区（LH）进行长期阈下电刺激，在食物动机的起始中枢建立了一个慢性兴奋灶。这种刺激导致了一种由食物动机强化的综合征的逐渐形成，表现为食物动机工具性反应的数量显著增加以及体重增加。同时，兔子表现出定向探究行为和总体运动活动的增强。所诱发的综合征与电刺激的开始没有紧密联系，并且在慢性电刺激停止后很长一段时间（2 - 4周）内持续存在且不减弱。从其发展特征、表现和持续性来看，该综合征明显不同于其他研究人员在对LH进行慢性电刺激时所获得的其他贪食现象。据推测，该综合征的基础是在食物动机的“起搏器”中形成了一个长期的兴奋发生器。
