Kryzhanovskiĭ G N, Kotov A V, Kulygina O A, Tolpygo S M, Sudakov K V
Biull Eksp Biol Med. 1977 Oct;84(10):405-8.
In the experiments on free behavior rabbits, tetanus toxin was injected into "pacemaker" motivational emotiogenic regions of the hypothalamus to form generators of pathologically enhanced excitation; this produced stable, long-term disorders in motivational-emotional behavior. The changes were manifested by intensification of the feeding behavior activity, including increase of the "secondary motivational reactions", intensification of the motor activity, excessive number of automatic masticatory movements, appearance of aggression, fear reaction and corresponding vegetative changes. The character of these reactions depended on the site of the toxin administration and on its dose. Formation of long-term generators of the pathologically enhanced excitation in the "pacemaker" motivational-emotiogenic centers of the hypothalamus by tetanus toxin can be used the modelling of psychopathological states in animals. The data obtained on the new model have confirmed the theory of generative mechanisms of neuropathological syndromes characterized by hyperactivity of the systems.
在对自由活动的兔子进行的实验中，将破伤风毒素注入下丘脑的“起搏器”动机性情绪发生区域，以形成病理性增强兴奋的发生器；这导致了动机-情绪行为的稳定、长期紊乱。这些变化表现为进食行为活动的增强，包括“次级动机反应”的增加、运动活动的增强、自动咀嚼动作过多、攻击行为的出现、恐惧反应以及相应的植物性变化。这些反应的特征取决于毒素给药的部位及其剂量。破伤风毒素在下丘脑的“起搏器”动机性情绪发生中心形成病理性增强兴奋的长期发生器，可用于动物精神病理状态的建模。在新模型上获得的数据证实了以系统多动为特征的神经病理综合征的发生机制理论。
