Olsson H, Brandt L
Br Med J. 1980 Oct 18;281(6247):1029-31. doi: 10.1136/bmj.281.6247.1029.
In a consecutive series of 150 women with breast cancer 122 had borne one or more children. Sixty-two patients were aged below 55 years at diagnosis (group A) and 60 were 55 years or older (group B). In group A 91 out of 153 children (59%) were boys compared with 48 out of 141 (34%) in group B (p=0.000007). In group A 54 of the 62 patients (87%) had given birth to one or more boys compared with 35 of the 60 (58%) in group B (p=0.0003). The mean age at diagnosis in mothers of two or more boys was 49.0 years, in those of one boy 55.2 years, and in those of only girls 61.0 years. The differences between each of the mean ages was significant. The mean age at diagnosis in 28 nulliparous patients was 57.7 years. There was no significant correlation between the number of female pregnancies and age at diagnosis. These results suggest that in women liable to develop breast cancer male pregnancies are associated with an early onset of the disease.
在连续的150例乳腺癌女性患者中，122例育有一个或多个子女。62例患者诊断时年龄小于55岁（A组），60例患者年龄为55岁及以上（B组）。A组153个子女中有91个（59%）为男孩，而B组141个子女中有48个（34%）为男孩（p=0.000007）。A组62例患者中有54例（87%）生育了一个或多个男孩，而B组60例中有35例（58%）（p=0.0003）。生育两个或更多男孩的母亲诊断时的平均年龄为49.0岁，生育一个男孩的母亲为55.2岁，只生育女孩的母亲为61.0岁。各平均年龄之间的差异具有显著性。28例未生育患者诊断时的平均年龄为57.7岁。女性怀孕次数与诊断时年龄之间无显著相关性。这些结果表明，在易患乳腺癌的女性中，怀有男性胎儿与疾病的早发有关。
