Adami H O, Rimsten A, Stenkvist B, Vegelius J
Cancer. 1978 Feb;41(2):747-57. doi: 10.1002/1097-0142(197802)41:2<747::aid-cncr2820410248>3.0.co;2-0.
Variables in reproductive histories were studied in 179 consecutively detected, unselected breast cancer patients and age-matched controls selected from a computerized population register. The comparison between patients and controls showed no significant difference in age at meanarche, age at first birth, age at menopause or number of children. A subdivision into pre- and post-menopausal women yielded no further information. These results are at variance with most earlier reports, possible because the controls here were selected from the whole female population instead of hospitalized patients. Our data do not support the view that it is possible to define groups at high risk for breast cancer on the basis of productive histories.
在179例连续检测出的、未经筛选的乳腺癌患者以及从计算机化人口登记册中选取的年龄匹配的对照者中,对生殖史变量进行了研究。患者与对照者之间的比较显示,在平均初潮年龄、首次生育年龄、绝经年龄或子女数量方面没有显著差异。将其细分为绝经前和绝经后女性也未获得更多信息。这些结果与大多数早期报告不同,可能是因为这里的对照者是从整个女性人群中选取的,而非住院患者。我们的数据不支持基于生殖史来定义乳腺癌高危人群的观点。