一种用于³H-胸腺嘧啶核苷标记指数的简单快速放射自显影技术及其在成人急性白血病治疗中的应用。

A simple rapid autoradiography for 3H-thymidine labeling index and its application to therapy of adult acute leukemia.

作者信息

Yoshida T, Hattori K I, Nakamura S, Mitamura E, Kobayashi S, Ohtake S, Tanimoto K

出版信息

Cancer. 1980 Nov 15;46(10):2298-2307. doi: 10.1002/1097-0142(19801115)46:10<2298::aid-cncr2820461029>3.0.co;2-g.

DOI:10.1002/1097-0142(19801115)46:10<2298::aid-cncr2820461029>3.0.co;2-g

Abstract

Our simple rapid autoradiography for 3H-thymidine (3H-TdR) labeling index (LI) of leukemic cells was introduced. Thirty-nine adult patients with acute nonlymphocytic leukemia were treated under a new protocol using 3H-TdR LI as a parameter and inserting a trial of partial synchronization by Ara-C. The success rate of synchronization by Ara-C (rise of the LI up to 10%) was 62.5% out of 32 courses. By our regimen the complete remission (CR) rate of 71.4% in 35 first treated cases, that of 44.0% in 25 courses of recurrent cases, and a median survival of 12 months were achieved. A survey of literature revealed that our results were favorably compared with others. Our new protocol is advantageous in permitting one to precisely know the proper time for chemotherapy and thus avoiding unnecessary side effects.

摘要

我们介绍了一种用于白血病细胞3H-胸腺嘧啶核苷（3H-TdR）标记指数（LI）的简单快速放射自显影方法。39例成年急性非淋巴细胞白血病患者按照新方案进行治疗，该方案以3H-TdR LI作为参数，并纳入了阿糖胞苷（Ara-C）诱导部分同步化的试验。在32个疗程中，Ara-C诱导同步化的成功率（LI升高至10%）为62.5%。按照我们的治疗方案，35例初治病例的完全缓解（CR）率为71.4%，25个复发病程的CR率为44.0%，中位生存期为12个月。文献调查显示，我们的结果与其他研究相比具有优势。我们的新方案的优势在于能够让人们精确知晓化疗的合适时机，从而避免不必要的副作用。