Lijinsky W, Saavedra J E, Reuber M D, Blackwell B N
Cancer Res. 1980 Sep;40(9):3325-7.
Three chlorinated nitrosopiperidines, 3-chloro-, 4-chloro-, and 3,4-dichloronitrosopiperidine, were administered to groups of 20 male Fischer 344 rats at a concentration of 0.17 mM in drinking water. Treatment with the monochloro compounds lasted for 30 weeks, while treatment with the dichloro compound lasted for 21 weeks. Almost all of the animals died with esophageal tumors. There was also a significant incidence of tumors of the forestomach and tongue in the rats treated with the monochloro compounds. Using the rate of death of the animals with tumors as an index, the relative potency of the three compounds increases from 3-chloro- to 4-chloro- to 3,4-dichloronitrosopiperidine.
将三种氯化亚硝基哌啶，即3-氯-、4-氯-和3,4-二氯亚硝基哌啶，以0.17 mM的浓度添加到饮用水中，分别给予每组20只雄性Fischer 344大鼠。单氯化合物的处理持续30周，而二氯化合物的处理持续21周。几乎所有动物都死于食管肿瘤。在用单氯化合物处理的大鼠中，前胃和舌头肿瘤的发生率也很高。以患肿瘤动物的死亡率为指标，三种化合物的相对效力从3-氯-亚硝基哌啶到4-氯-亚硝基哌啶再到3,4-二氯亚硝基哌啶逐渐增加。
