Lijinsky W, Taylor H W
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1978 Sep 28;92(2):217-20. doi: 10.1007/BF00312411.
4-Chloronitrosopiperidine was administered to a group of 15 male Sprague-Dawley rats as a 0.005% solution in drinking water for 27 weeks. Of the 15 animals, 12 died with tumors induced by the treatment, half of them by the 41 st week; all 15 were dead at 58 weeks. Seven rats had liver tumors, 5 had esophageal tumors, 2 had tumors of the nonglandular stomach and 2 had tumors of the nasal turbinates. Several rats had tumors of more than one organ.
将4-氯亚硝基哌啶以0.005%的溶液形式加入饮用水中，给15只雄性斯普拉格-道利大鼠饮用27周。15只动物中，12只因治疗诱发肿瘤死亡，其中一半在第41周时死亡；所有15只在58周时全部死亡。7只大鼠患有肝肿瘤，5只患有食管肿瘤，2只患有非腺胃肿瘤，2只患有鼻甲肿瘤。几只大鼠有不止一个器官发生肿瘤。
