Nishioka K, Ezaki K, Hart J S
Clin Chim Acta. 1980 Oct 23;107(1-2):59-66. doi: 10.1016/0009-8981(80)90414-3.
Polyamines (mainly putrescine, spermidine, and spermine) whose biosynthesis is a prerequisite for cell proliferation, are potential indicators of malignant growth. To investigate the mechanism of alterations of polyamine levels in physiological fluids in human cancer, polyamine levels of bone-marrow plasma from adult patients with leukemia were studied. Significant correlations were observed between bone-marrow cellularity and spermidine, between peripheral white blood cell counts and spermidine and spermine, and between absolute blast count and spermidine and spermine among untreated patients with acute leukemia. Untreated patients with chronic leukemia showed significantly elevated levels of polyamines relative to untreated patients with acute leukemia, indicating a higher turnover of bone-marrow cells in chronic leukemia than in acute leukemia. Chemotherapy-treated patients with acute leukemia who were in remission or who did not respond to the agent showed low polyamine levels. Patients who showed a destruction of tumor cell during chemotherapy gave high levels of polyamines. Overall, these studies indicate that elevated polyamine levels are markers of cell death.
多胺（主要是腐胺、亚精胺和精胺）的生物合成是细胞增殖的前提条件，是恶性生长的潜在指标。为了研究人类癌症患者生理体液中多胺水平变化的机制，对成年白血病患者骨髓血浆中的多胺水平进行了研究。在未经治疗的急性白血病患者中，观察到骨髓细胞密度与亚精胺之间、外周血白细胞计数与亚精胺和精胺之间、原始细胞绝对计数与亚精胺和精胺之间存在显著相关性。未经治疗的慢性白血病患者相对于未经治疗的急性白血病患者，多胺水平显著升高，表明慢性白血病患者骨髓细胞的更新率高于急性白血病患者。处于缓解期或对药物无反应的接受化疗的急性白血病患者多胺水平较低。在化疗期间肿瘤细胞被破坏的患者多胺水平较高。总体而言，这些研究表明多胺水平升高是细胞死亡的标志物。
