灌注大鼠心脏中丙酸盐对乙酰乙酸氧化的增强作用。
Propionate enhancement of acetoacetate oxidation in perfused rat hearts.
作者信息
Revsin-Lanier B, Lebowitz J, Morrow G
出版信息
Clin Sci (Lond). 1980 Oct;59(4):289-92. doi: 10.1042/cs0590289.
PMID:7428296
Abstract
- Isolated perfused rat hearts, acetoacetate oxidation was significantly enhanced by propionate. 2. No enhancement of acetoacetate oxidation could be observed in vitamin B12-deficient rat hearts when propionate was present. 3. Although the mechanisms of enhancement are not clear, ketone clearance is enhanced by propionate and may provide an insight into the therapy of certain diseases characterized by ketosis.
摘要
- 在离体灌注的大鼠心脏中，丙酸盐可显著增强乙酰乙酸的氧化。2. 当存在丙酸盐时，在维生素B12缺乏的大鼠心脏中未观察到乙酰乙酸氧化增强。3. 虽然增强机制尚不清楚，但丙酸盐可增强酮体清除，这可能为某些以酮症为特征的疾病的治疗提供思路。
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