Peirce T H, Kenny R A, Dawson A F, Hobbs P M
Curr Med Res Opin. 1980;6(10):649-52. doi: 10.1185/03007998009110075.
Levels of cefuroxime in bronchial secretion were measured in 49 patients requiring bronchoscopy for diagnostic purposes. Patients were randomly allocated to one of 4 groups which differed with respect to the size (750 mg or 1.5 g) and number (1 or 7) of intravenous doses of cefuroxime given approximately 1 hour prior to sampling. Levels of cefuroxime achieved after administration of all 4 dosages were sufficient to exceed the MIC values for the major chest pathogens. Penetration of cefuroxime into bronchial secretion was also found to be dose-related.
对49名因诊断目的需要进行支气管镜检查的患者的支气管分泌物中的头孢呋辛水平进行了测量。患者被随机分配到4组中的一组，这4组在取样前约1小时静脉注射头孢呋辛的剂量大小（750毫克或1.5克）和数量（1次或7次）方面有所不同。给予所有4种剂量后所达到的头孢呋辛水平足以超过主要胸部病原体的最低抑菌浓度值。还发现头孢呋辛向支气管分泌物中的渗透与剂量有关。
