Korthals J K, Korthals M A, Wisniewski H M
Ann Neurol. 1978 Dec;4(6):487-98. doi: 10.1002/ana.410040603.
Following simultaneous ligation of the aorta and femoral artery in the cat, organelles accumulated in distal portions of the sciatic nerve and in lower portions of the tibial and peroneal nerves. The accumulations were located in the proximal and distal ends of the nerve infarction and delineated the borders of the necrotic area. Topographical analysis of the necrosis and organelle accumulations following ligation of these main arteries showed the larger nerve fascicles to be more sensitive to ischemia than the smaller ones. The center of a nerve fascicle was more sensitive than the periphery. The organelles accumulated in ischemic nerves during the first hours after arterial ligation, presumably as a result of lack of energy for fast axoplasmic transport. Later accumulations reflected mechanical block of axoplasmic transport due to focal necrosis of the nerve. The content of organelle accumulations was similar to that found in lesions resulting from transection except for the presence of 60 to 70 A filaments at the distal end of the infarction.
在猫的主动脉和股动脉同时结扎后，细胞器积聚在坐骨神经的远端部分以及胫神经和腓总神经的下部。这些积聚位于神经梗死的近端和远端，勾勒出坏死区域的边界。对这些主要动脉结扎后坏死和细胞器积聚的地形分析表明，较大的神经束比较小的神经束对缺血更敏感。神经束的中心比周边更敏感。动脉结扎后的最初几个小时内，细胞器积聚在缺血神经中，这可能是由于快速轴浆运输缺乏能量所致。后来的积聚反映了由于神经局灶性坏死导致的轴浆运输机械性阻塞。细胞器积聚的内容物与横断损伤中发现的相似，只是在梗死远端存在60至70埃的细丝。
