Parry G J, Brown M J
Ann Neurol. 1982 Feb;11(2):147-54. doi: 10.1002/ana.410110207.
To study the relationship between fiber size and vulnerability to ischemia, we produced partial infarction of the proximal posterior tibial nerve of Wistar rats by injecting arachidonic acid into the ipsilateral femoral artery. In the resulting lesion degenerating fibers were concentrated in the center of the nerve. Distal to the infarct, surviving myelinated and unmyelinated fibers were evenly distributed throughout both fascicles. Smaller myelinated fibers (less than 6 micrometers in diameter) were more severely depleted than larger ones ( greater than 6 micrometer). Unmyelinated fibers were reduced in number in proportion to or to a greater extent than myelinated fibers. These findings demonstrate that large myelinated fibers are relatively less vulnerable to peripheral nerve ischemia than smaller fibers, and do not support the contention that unmyelinated fibers are inherently resistant to acute ischemia.
为了研究纤维大小与缺血易损性之间的关系，我们通过向同侧股动脉注射花生四烯酸，造成了Wistar大鼠胫后神经近端的部分梗死。在由此产生的病变中，变性纤维集中在神经中心。在梗死远端，存活的有髓和无髓纤维均匀分布于两个束内。直径小于6微米的较小有髓纤维比直径大于6微米的较大有髓纤维消耗更严重。无髓纤维数量减少的比例与有髓纤维相同或更大。这些发现表明，与较小纤维相比，大的有髓纤维对外周神经缺血相对不易受损，并且不支持无髓纤维天生对急性缺血有抵抗力的观点。
