Wehrenberg W B, McNicol D, Frantz A G, Ferin M
Endocrinology. 1980 Dec;107(6):1747-50. doi: 10.1210/endo-107-6-1747.
The effects of serotonin on PRL and GH secretion were studied in normal and pituitary stalk-sectioned female rhesus monkeys. Serotonin was administered iv at doses of 50, 500, 5000 microgram. Pretreatment concentrations of serum PRL were elevated in stalk-sectioned monkeys compared to normal monkeys [34 +/- 5 vs. 3 +/- 1 ng/ml (mean +/- SEM)], while serum GH concentrations were lower in the stalk-sectioned animals (< 0.5 vs. 1.3 +/- 0.2 ng/ml). In both normal and stalk-sectioned monkeys, the 5-microgram dose of serotonin failed to alter PRL concentrations. However, with the 500-microgram dose, PRL rose from 3 +/- 1 to 22 +/- 6 ng/ml in normal monkeys and from 27 +/- 6 to 57 +/- 10 ng/ml in stalk-sectioned monkeys. Likewise, with the 5000-microgram dose, PRL rose from 4 +/- 2 to 82 +/- 27 and from 30 +/- 6 to 75 +/- 26 ng/ml in the two respective groups. No dose of serotonin stimulated GH secretion in stalk-sectioned monkeys, although GH did increase from approximately 2 to 4-11 ng/ml in normal monkeys. Since the pituitary is devoid of direct hypothalamic influences in the pituitary stalk-sectioned animals, these results suggest that serotonin can modulate PRL secretion either directly at the pituitary level or via some yet to be determined peripheral mechanism. In contrast, this neurotransmitter appears to incorporate hypothalamic factors in its modulation of GH secretion.
在正常和垂体柄横断的雌性恒河猴中研究了血清素对催乳素（PRL）和生长激素（GH）分泌的影响。静脉注射血清素，剂量分别为50、500、5000微克。与正常猴子相比，垂体柄横断的猴子血清PRL的预处理浓度升高[34±5 vs. 3±1纳克/毫升（平均值±标准误）]，而垂体柄横断动物的血清GH浓度较低（<0.5 vs. 1.3±0.2纳克/毫升）。在正常和垂体柄横断的猴子中，5微克剂量的血清素未能改变PRL浓度。然而，500微克剂量时，正常猴子的PRL从3±1升高到22±6纳克/毫升，垂体柄横断的猴子从27±6升高到57±10纳克/毫升。同样，5000微克剂量时，两组中PRL分别从4±2升高到82±27以及从30±6升高到75±26纳克/毫升。在垂体柄横断的猴子中，没有剂量的血清素能刺激GH分泌，尽管在正常猴子中GH确实从大约2升高到4 - 11纳克/毫升。由于在垂体柄横断的动物中垂体缺乏直接的下丘脑影响，这些结果表明血清素可以在垂体水平直接调节PRL分泌，或者通过一些尚未确定的外周机制。相比之下，这种神经递质在调节GH分泌时似乎整合了下丘脑因素。
