胃泌素、促胰液素、胆囊收缩素、胰高血糖素及胃抑肽联合应用对人体空肠吸收的影响
Effect of a combination of gastrin, secretin, cholecystokinin, glucagon, and gastric inhibitory polypeptide on jejunal absorption in man.
作者信息
Poitras P, Modigliani R, Bernier J J
出版信息
Gut. 1980 Apr;21(4):299-304. doi: 10.1136/gut.21.4.299.
Abstract
In 11 conscious volunteers, the jejunal absorption was measured during basal state and during the simultaneous intravenous infusion of small doses of gastrin, secretin, cholecystokinin, glucagon and gastric inhibitory polypeptide. The blood levels of gastrin, secretin, glucagon, and GIP were measured by RIA and were close to those achieved after a meal. The basal net absorption of water and electrolytes was reversed to a net secretion during the hormonal infusion. These results suggest that the jejunal secretion observed after a meal in man may be mediated by hormones released by the meal.
摘要
在11名清醒志愿者中，测量了基础状态下以及同时静脉输注小剂量胃泌素、促胰液素、胆囊收缩素、胰高血糖素和胃抑制多肽期间空肠的吸收情况。采用放射免疫分析法测定了胃泌素、促胰液素、胰高血糖素和胃抑制多肽的血药浓度，这些浓度与进食后达到的浓度相近。激素输注期间，水和电解质的基础净吸收转变为净分泌。这些结果表明，人进食后观察到的空肠分泌可能由进食释放的激素介导。
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