Ipp E, Dobbs R E, Harris V, Arimura A, Vale W, Unger R H
J Clin Invest. 1977 Nov;60(5):1216-9. doi: 10.1172/JCI108875.
The effects of gastrin, gastric inhibitory polypeptide, secretin, and the octapeptide of pancreozymin-cholecystokinin on immunoreactive somatostatin release were studied in the isolated perfused dog pancreas. Gastrin at a concentration of 65 ng/ml and the octapeptide of pancreozymin-cholecystokinin at a concentration of 25 ng/ml produced a prompt, but transient statistically significant, twofold rise in mean somatostatin concentration. Secretion at a concentration of 0.3 U/ml and gastric inhibitory polypeptide concentration of 58 ng/ml produced a prompt two- to threefold rise in mean somatostatin release, which persisted throughout the perfusion period. With all four polypeptides the pattern of the somatostatin response resembled that of insulin. It appears that pancreatic somatostatin release is stimulated by gastrointestinal hormones that influence the secretion of insulin and glucagon.
在离体灌注的犬胰腺中，研究了胃泌素、胃抑制性多肽、促胰液素和胰酶泌素 - 胆囊收缩素八肽对免疫反应性生长抑素释放的影响。浓度为65 ng/ml的胃泌素和浓度为25 ng/ml的胰酶泌素 - 胆囊收缩素八肽使生长抑素平均浓度迅速但短暂地出现统计学上显著的两倍升高。浓度为0.3 U/ml的促胰液素和浓度为58 ng/ml的胃抑制性多肽使生长抑素平均释放迅速升高两到三倍，且在整个灌注期持续存在。对于所有这四种多肽，生长抑素反应模式类似于胰岛素。似乎胰腺生长抑素释放受到影响胰岛素和胰高血糖素分泌的胃肠激素的刺激。
