熊去氧胆酸治疗与胆汁脂质——一项剂量反应研究。
Ursodeoxycholic acid therapy and biliary lipids--a dose-response study.
作者信息
Bateson M C, Ross P E, Murison J, Saunders J H, Bouchier I A
出版信息
Gut. 1980 Apr;21(4):305-10. doi: 10.1136/gut.21.4.305.
Abstract
The effects of four different doses of ursodeoxycholic acid (250, 500, 750, and 1000 mg daily) on biliary lipids were studied in 24 patients with radiolucent gallbladder stones. There was a significant increase in the proportion of ursodeoxycholic acid in bile after all doses, being greatest with 750 and 1000 mg daily. Unsulphated lithocholic acid was also increased in the bile after therapy, while the other major bile acids were reduced. The cholesterol content of bile was reduced by all doses, and this change was most marked after 1000 mg (from 10.9 +/- 1.4 to 5.6 +/- 0.5 mol%, P < 0.01). Biliary cholesterol saturation improved significantly only after 750 and 1000 mg daily.
摘要
在24例胆囊阴性结石患者中研究了四种不同剂量的熊去氧胆酸（每日250、500、750和1000毫克）对胆汁脂质的影响。所有剂量给药后胆汁中熊去氧胆酸的比例均显著增加，每日750毫克和1000毫克时增加最为明显。治疗后胆汁中未硫酸化的石胆酸也增加，而其他主要胆汁酸减少。所有剂量均使胆汁中的胆固醇含量降低，1000毫克后这种变化最为显著（从10.9±1.4降至5.6±0.5摩尔%，P<0.01）。仅每日750毫克和1000毫克时胆汁胆固醇饱和度显著改善。
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