克罗恩病中的锌吸收
Zinc absorption in Crohn's disease.
作者信息
Sturniolo G C, Molokhia M M, Shields R, Turnberg L A
出版信息
Gut. 1980 May;21(5):387-91. doi: 10.1136/gut.21.5.387.
Zinc deficiency is a potential complication of Crohn's disease and we have searched for evidence of this and assessed the possibility that malabsorption of zinc might be a cause. Serum zinc concentrations in 33 patients suffering from Crohn's disease were significantly lower than in 58 normal control subjects (9 . 18 +/- 2 . 3 mumol compared with 13 . 6 +/- 1 . 73 mumol, P < 0 . 0005). Serum zinc correlated well with serum albumin concentrations and the low serum zinc may simply reflect the low serum albumin. Thus its value as an indicator of zinc deficiency is poor. We studied zinc absorption in seven patients with Crohn's disease and compared it with the results obtained previously in five normal subjects using a new technique involving a short-lived isotope of zinc (69mZn). Plasma appearance curves, constructed after an oral dose of isotope, and disappearance curves, after an intravenous dose, were used in a deconvolution computer programme to calculate zinc absorption. Compared with normal subjects, zinc absorption was considerably impaired in patients with Crohn's disease (range 9--45%, compared with 38--75%). This abnormality is a potential cause of zinc deficiency in patients with Crohn's disease.
锌缺乏是克罗恩病的一种潜在并发症，我们已寻找相关证据并评估锌吸收不良可能是其病因的可能性。33例克罗恩病患者的血清锌浓度显著低于58例正常对照者（分别为9.18±2.3 μmol和13.6±1.73 μmol，P<0.0005）。血清锌与血清白蛋白浓度密切相关，低血清锌可能仅仅反映了低血清白蛋白水平。因此，其作为锌缺乏指标的价值不大。我们研究了7例克罗恩病患者的锌吸收情况，并使用一种涉及锌的短寿命同位素（69mZn）的新技术，将其与之前在5例正常受试者中获得的结果进行比较。口服同位素后构建血浆出现曲线，静脉注射后构建消失曲线，利用反卷积计算机程序计算锌吸收情况。与正常受试者相比，克罗恩病患者的锌吸收明显受损（范围为9% - 45%，而正常人为38% - 75%）。这种异常是克罗恩病患者锌缺乏的一个潜在原因。
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