Walker B E, Dawson J B, Kelleher J, Losowsky M S
Gut. 1973 Dec;14(12):943-8. doi: 10.1136/gut.14.12.943.
Plasma and urinary zinc have been measured in 19 patients with malabsorption and 21 patients with hepatic cirrhosis. The results have been compared with those of 20 control subjects and 23 patients with a variety of other diseases. The diurnal variation in plasma zinc levels has been confirmed and is of such magnitude that this must be taken into account in comparing results in groups of subjects. Plasma zinc levels, both fasting and after a meal, are significantly lower in patients with cirrhosis (71 and 60 mug/100 ml) and malabsorption (76 and 64 mug/100 ml) than in controls (97 and 81 mug/100 ml). In the patients with cirrhosis or malabsorption similar correlations exist between plasma zinc and plasma albumin, suggesting that the low plasma zinc levels may be, at least in part, dependent on the plasma albumin level. Urinary zinc excretion is increased in cirrhosis, but not in malabsorption, indicating that increased urinary loss is unlikely to explain the low plasma levels.
对19名吸收不良患者和21名肝硬化患者的血浆和尿液锌含量进行了测定。并将结果与20名对照受试者以及23名患有其他各种疾病的患者的结果进行了比较。已证实血浆锌水平存在昼夜变化，其幅度之大，以至于在比较各组受试者的结果时必须予以考虑。肝硬化患者（71和60微克/100毫升）和吸收不良患者（76和64微克/100毫升）空腹和餐后的血浆锌水平均显著低于对照组（97和81微克/100毫升）。在肝硬化或吸收不良患者中，血浆锌与血浆白蛋白之间存在相似的相关性，这表明血浆锌水平低可能至少部分取决于血浆白蛋白水平。肝硬化患者的尿锌排泄增加，但吸收不良患者则不然，这表明尿锌流失增加不太可能解释血浆锌水平低的原因。
