Draese K, Hirche H
Fortschr Med. 1980 Oct 16;98(39):1529-33.
Besides the high diagnostical value of the electromanometric measurement, this method is especially useful for the registration of pharmacological effects upon the sphincter of Oddi. In this study the influence of hymecromon on sphincter function was tested in 138 patients. Hymecromon induced a significant decrease of pressure by prolonging the opening time (p < 0.001). In clinical experiments it could be shown that the increase of pressure induced by morphine in the common bile duct could be equalized by hymecromon within a short time. Depending significantly on the dosage (p < 0.01) there were identical results on the intravenous or intraductal application of hymecromon. An increase of activity of the liver-specific enzymes could not be seen after hymecromon treatment.
除了电子测压法具有较高的诊断价值外，该方法对于记录药物对Oddi括约肌的作用尤其有用。在本研究中，对138例患者测试了羟甲香豆素对括约肌功能的影响。羟甲香豆素通过延长开放时间导致压力显著降低（p<0.001）。在临床实验中可以表明，羟甲香豆素能在短时间内抵消吗啡引起的胆总管压力升高。羟甲香豆素静脉内或导管内给药的效果显著取决于剂量（p<0.01），结果相同。羟甲香豆素治疗后未观察到肝脏特异性酶活性增加。
