McFarland R J, Corbett C R, Taylor P, Nash A G
Br J Clin Pharmacol. 1984 Jun;17(6):766-8. doi: 10.1111/j.1365-2125.1984.tb02416.x.
The retained stone in the common bile duct remains a problem for the surgeon. Although more effective methods are available, mechanical flushing of the bile duct is, when successful, a simple solution. Pharmacological dilatation of the sphincter of Oddi is a logical adjunct to flushing. Pressure changes in the bile duct during flushing were studied in 20 postoperative patients with T-tube drains and the effectiveness of two drugs in reducing Omnopon induced spasm of the sphincter was compared. Hymecromone intravenously and lignocaine via the T-tube were equally effective, reducing sphincter activity in the majority of patients, but there was considerable individual variation.
胆总管内残留结石仍是外科医生面临的一个问题。尽管有更有效的方法，但胆管机械冲洗若成功，是一种简单的解决办法。对奥狄括约肌进行药物扩张是冲洗的合理辅助手段。对20例带T形管引流的术后患者在冲洗过程中胆管内的压力变化进行了研究，并比较了两种药物减轻Omnopon引起的括约肌痉挛的效果。静脉注射羟甲香豆素和通过T形管注入利多卡因同样有效，可降低大多数患者的括约肌活动，但个体差异较大。
