Ingram D L, Kaciuba-Uscilko H
Horm Metab Res. 1980 Sep;12(9):430-3. doi: 10.1055/s-2007-999167.
The i.v. infusion or i.m. injection of 30 micrograms x kg-1 of glucagon into pigs aged 3--9 d, 24--30 d and 42--56 d was followed by a rise in the rate of oxygen consumption. In pigs aged 3--28 d pretreatment with 3 mg/kg of the beta-blocker propranolol prevented the rise in oxygen consumption after glucagon. Glucagon also caused a rise in plasma glucose which persisted for 60 min in 3--9 d old pigs. In older animals the glucose concentration first increased and then decreased below the control value after 45 min before rising again. The plasma concentration of free fatty acids did not change. In older pigs glucagon often induced shivering which occurred after the initial rise in metabolic rate. This effect which was accompanied by an increase in body temperature could be blocked with indomethacin, but the initial rise in metabolic rate, which was not associated with shivering, persisted.
给3至9日龄、24至30日龄和42至56日龄的猪静脉注射或肌肉注射30微克/千克的胰高血糖素后，耗氧率上升。在3至28日龄的猪中，用3毫克/千克的β受体阻滞剂普萘洛尔预处理可防止胰高血糖素注射后耗氧率上升。胰高血糖素还可使血浆葡萄糖升高，在3至9日龄的猪中，这种升高持续60分钟。在年龄较大的动物中，葡萄糖浓度先升高，然后在45分钟后降至对照值以下，之后再次升高。游离脂肪酸的血浆浓度没有变化。在年龄较大的猪中，胰高血糖素常诱发颤抖，这种颤抖发生在代谢率最初升高之后。这种伴有体温升高的效应可被吲哚美辛阻断，但与颤抖无关的代谢率最初升高仍持续存在。
