豚鼠非黏附性单核细胞和多形核细胞介导的抗体依赖的细胞介导的细胞毒性作用
ADCC mediated by non-adherent mononuclear and polymorphonuclear cells of the guinea-pig.
作者信息
Hopkins S J, Dale M M
出版信息
Immunology. 1980 Aug;40(4):513-9.
Various cell populations of the guinea-pig have been assessed for their capacity to mediate antibody-dependent cellular cytotoxicity (ADCC) against guinea-pig and mouse tumour cell targets. Activity was found to be present in the spleen and blood but was absent in lymph nodes. Macrophages did not appear to lyse target cells in the system used and cytotoxicity among the mononuclear (MN) cells was confined to the non-adherent cells. Considerable lysis was induced by polymorphonuclear (PMN) cells in the presence of antiserum and their activity was greater than that of equivalent numbers of spleen MN cells. The lytic activity of PMN cells appeared to be specific for antibody coated target cells since uncoated bystander cells were not lysed.
对豚鼠的各种细胞群体针对豚鼠和小鼠肿瘤细胞靶标的抗体依赖性细胞毒性（ADCC）介导能力进行了评估。发现脾脏和血液中有活性，但淋巴结中没有。在所使用的系统中，巨噬细胞似乎不会裂解靶细胞，单核（MN）细胞中的细胞毒性仅限于非贴壁细胞。在抗血清存在的情况下，多形核（PMN）细胞诱导了相当程度的裂解，并且它们的活性大于等量脾脏MN细胞的活性。PMN细胞的裂解活性似乎对抗体包被的靶细胞具有特异性，因为未包被的旁观者细胞不会被裂解。
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