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IgE 抗体产生中的抗原竞争。I. 初次和二次反应相关参数的确定。

Antigenic competition in IgE antibody production. I. Establishment of parameters involved in primary and secondary responses.

作者信息

de Macedo M S, Mota I

出版信息

Immunology. 1980 Aug;40(4):701-8.

PMID:7429547
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1458095/
Abstract

Antigenic competition was demonstrated in IgE antibody response in mice immunized with ovalbumin or DNP-ovalbumin associated with several non-related proteins: DNP-Ascaris, DNP-keyhole limpet haemocyanin or Ascaris. Simultaneous injection of two antigens caused a suppression of IgE antibody production to the test antigen, IgG1 antibody formation being only diminished under certain conditions. Competition was dose-dependent and effective only in the primary response. However, the secondary response could be also partially suppressed if the competitor antigen was given in both first and second antigenic stimulation. Competition was abolished by irradiation prior to immunization.

摘要

在用卵清蛋白或与几种无关蛋白质相关的二硝基苯基卵清蛋白（DNP-卵清蛋白）免疫的小鼠的IgE抗体反应中证实了抗原竞争：二硝基苯基蛔虫（DNP-蛔虫）、二硝基苯基钥孔戚血蓝蛋白或蛔虫。同时注射两种抗原会导致针对测试抗原的IgE抗体产生受到抑制，只有在某些条件下IgG1抗体形成才会减少。竞争是剂量依赖性的，并且仅在初次反应中有效。然而，如果在初次和第二次抗原刺激中都给予竞争抗原，二次反应也可能被部分抑制。免疫前照射可消除竞争。

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本文引用的文献

1
Passive cutaneous anaphylaxis in the mouse.小鼠被动皮肤过敏反应
J Immunol. 1958 Oct;81(4):355-7.
2
Hypersensitivity to Ascaris antigens. I. Skin-sensitizing activity of serum fractions from guinea pigs sensitized to crude extracts.对蛔虫抗原的超敏反应。I. 对粗提物致敏的豚鼠血清组分的皮肤致敏活性。
J Immunol. 1967 May;98(5):893-900.
3
Relationship between histocompatibility (H-2) genotype and immune responsiveness to low doses of ovalbumin in the mouse.小鼠组织相容性（H-2）基因型与对低剂量卵清蛋白免疫反应性之间的关系。
J Immunol. 1970 Jun;104(6):1572-4.
4
Homologous and heterologous passive cutaneous anaphylactic activity of mouse antisera during the course of immunization.小鼠抗血清在免疫过程中的同源和异源被动皮肤过敏活性。
Life Sci. 1969 Aug 15;8(16):813-20. doi: 10.1016/0024-3205(69)90099-x.
5
Antigenic competition: a review of nonspecific antigen-induced suppression.抗原竞争：非特异性抗原诱导抑制的综述
Adv Immunol. 1974;18:133-68. doi: 10.1016/s0065-2776(08)60309-0.
6
Regulation of homocytotropic antibody formation in the rat. VI. Inhibitory effect of thymocytes on the homocytotropic antibody response.大鼠中亲同种细胞抗体形成的调节。VI. 胸腺细胞对亲同种细胞抗体反应的抑制作用。
J Immunol. 1971 Dec;107(6):1682-9.
7
Regulation of homocytotropic antibody formation in the rat. II. Effect of X-irradiation.大鼠中亲同种细胞抗体形成的调节。II. X射线照射的影响。
J Immunol. 1971 Apr;106(4):1012-8.
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Antigenic competition between heterologous erythrocytes. I. Thymic dependency.异种红细胞之间的抗原竞争。I. 胸腺依赖性。
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Studies on antigenic competition. Efforts to identify the cellular basis of competition using a cell transfer system.
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10
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J Immunol. 1973 Sep;111(3):952-61.

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