• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

IgE 抗体产生中的抗原竞争。I. 初次和二次反应相关参数的确定。

Antigenic competition in IgE antibody production. I. Establishment of parameters involved in primary and secondary responses.

作者信息

de Macedo M S, Mota I

出版信息

Immunology. 1980 Aug;40(4):701-8.

PMID:7429547
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1458095/
Abstract

Antigenic competition was demonstrated in IgE antibody response in mice immunized with ovalbumin or DNP-ovalbumin associated with several non-related proteins: DNP-Ascaris, DNP-keyhole limpet haemocyanin or Ascaris. Simultaneous injection of two antigens caused a suppression of IgE antibody production to the test antigen, IgG1 antibody formation being only diminished under certain conditions. Competition was dose-dependent and effective only in the primary response. However, the secondary response could be also partially suppressed if the competitor antigen was given in both first and second antigenic stimulation. Competition was abolished by irradiation prior to immunization.

摘要

在用卵清蛋白或与几种无关蛋白质相关的二硝基苯基卵清蛋白（DNP-卵清蛋白）免疫的小鼠的IgE抗体反应中证实了抗原竞争：二硝基苯基蛔虫（DNP-蛔虫）、二硝基苯基钥孔戚血蓝蛋白或蛔虫。同时注射两种抗原会导致针对测试抗原的IgE抗体产生受到抑制，只有在某些条件下IgG1抗体形成才会减少。竞争是剂量依赖性的，并且仅在初次反应中有效。然而，如果在初次和第二次抗原刺激中都给予竞争抗原，二次反应也可能被部分抑制。免疫前照射可消除竞争。

相似文献

1
Antigenic competition in IgE antibody production. I. Establishment of parameters involved in primary and secondary responses.IgE 抗体产生中的抗原竞争。I. 初次和二次反应相关参数的确定。
Immunology. 1980 Aug;40(4):701-8.
2
Antigenic competition in IgE antibody production. II. Effect of cyclophosphamide.IgE抗体产生中的抗原竞争。II. 环磷酰胺的作用。
Immunology. 1982 Sep;47(1):67-74.
3
Regulation of antibody response in different immunoglobulin classes. II. Induction of in vitro IgE antibody response in murine spleen cells and demonstration of a possible involvement of distinct T-helper cells in IgE and IgG antibody responses.不同免疫球蛋白类别的抗体应答调节。II. 小鼠脾细胞体外IgE抗体应答的诱导以及不同T辅助细胞可能参与IgE和IgG抗体应答的证明。
J Immunol. 1977 Mar;118(3):840-5.
4
Immunosuppressive effects of glycosylation inhibiting factor on the IgE and IgG antibody response.糖基化抑制因子对IgE和IgG抗体应答的免疫抑制作用。
J Immunol. 1986 May 1;136(9):3172-9.
5
Reaginic antibody production to Ascaris suum allergen, ASC-1. I. The function of glutaraldehyde-polymerized antigen in the induction of reaginic (IgE) antibodies in the rat.针对猪蛔虫变应原ASC-1产生反应素抗体。I. 戊二醛聚合抗原在大鼠体内诱导反应素（IgE）抗体产生中的作用
Int Arch Allergy Appl Immunol. 1977;54(6):487-501.
6
Suppressive effect of an Ascaris suum extract on IgE and IgG antibody responses in mice.
Braz J Med Biol Res. 1987;20(2):203-11.
7
Adjuvant and suppressive effects of Grass Conjuvac and other alginate conjugates on IgG and IgE antibody responses in mice.草结合疫苗及其他藻酸盐偶联物对小鼠IgG和IgE抗体反应的佐剂和抑制作用。
Immunology. 1981 Sep;44(1):41-50.
8
Relationships between cell-mediated immunity and the IgE antibody response. I. Lymphotoxin production to DNP-Ascaris conjugates.
Cell Immunol. 1980 Aug 15;54(1):140-54. doi: 10.1016/0008-8749(80)90197-5.
9
Reaginic antibody formation in the mouse. X. Possible role of suppressor T cells in transient IgE antibody responses.小鼠中反应素抗体的形成。X. 抑制性T细胞在短暂性IgE抗体应答中的可能作用。
J Immunol. 1978 Mar;120(3):837-43.
10
Regulation of immune response by preadministration of cells briefly pulsed with antigen in vitro. I. Suppression of IgE antibody response by antigen pulsed spleen cells.
Int Arch Allergy Appl Immunol. 1982;69(2):98-108. doi: 10.1159/000233155.

引用本文的文献

1
Infection with Syphacia obvelata (pinworm) induces protective Th2 immune responses and influences ovalbumin-induced allergic reactions.感染欧氏管状线虫（蛲虫）可诱导保护性Th2免疫反应，并影响卵清蛋白诱导的过敏反应。
Infect Immun. 2006 Oct;74(10):5926-32. doi: 10.1128/IAI.00207-06.
2
The immunosuppressive activity of Ascaris suum is due to high molecular weight components.猪蛔虫的免疫抑制活性归因于高分子量成分。
Clin Exp Immunol. 1998 Nov;114(2):245-51. doi: 10.1046/j.1365-2249.1998.00723.x.
3
Antigenic competition in IgE antibody production. II. Effect of cyclophosphamide.IgE抗体产生中的抗原竞争。II. 环磷酰胺的作用。
Immunology. 1982 Sep;47(1):67-74.

本文引用的文献

1
Passive cutaneous anaphylaxis in the mouse.小鼠被动皮肤过敏反应
J Immunol. 1958 Oct;81(4):355-7.
2
Hypersensitivity to Ascaris antigens. I. Skin-sensitizing activity of serum fractions from guinea pigs sensitized to crude extracts.对蛔虫抗原的超敏反应。I. 对粗提物致敏的豚鼠血清组分的皮肤致敏活性。
J Immunol. 1967 May;98(5):893-900.
3
Relationship between histocompatibility (H-2) genotype and immune responsiveness to low doses of ovalbumin in the mouse.小鼠组织相容性（H-2）基因型与对低剂量卵清蛋白免疫反应性之间的关系。
J Immunol. 1970 Jun;104(6):1572-4.
4
Homologous and heterologous passive cutaneous anaphylactic activity of mouse antisera during the course of immunization.小鼠抗血清在免疫过程中的同源和异源被动皮肤过敏活性。
Life Sci. 1969 Aug 15;8(16):813-20. doi: 10.1016/0024-3205(69)90099-x.
5
Antigenic competition: a review of nonspecific antigen-induced suppression.抗原竞争：非特异性抗原诱导抑制的综述
Adv Immunol. 1974;18:133-68. doi: 10.1016/s0065-2776(08)60309-0.
6
Regulation of homocytotropic antibody formation in the rat. VI. Inhibitory effect of thymocytes on the homocytotropic antibody response.大鼠中亲同种细胞抗体形成的调节。VI. 胸腺细胞对亲同种细胞抗体反应的抑制作用。
J Immunol. 1971 Dec;107(6):1682-9.
7
Regulation of homocytotropic antibody formation in the rat. II. Effect of X-irradiation.大鼠中亲同种细胞抗体形成的调节。II. X射线照射的影响。
J Immunol. 1971 Apr;106(4):1012-8.
8
Antigenic competition between heterologous erythrocytes. I. Thymic dependency.异种红细胞之间的抗原竞争。I. 胸腺依赖性。
J Immunol. 1971 Jun;106(6):1524-31.
9
Studies on antigenic competition. Efforts to identify the cellular basis of competition using a cell transfer system.
Cell Immunol. 1974 Jul;13(1):66-75. doi: 10.1016/0008-8749(74)90227-5.
10
Regulation of homocytotropic antibody formation in the rat. 8. An antigen-specific T cell factor that regulates anti-hapten homocytotropic antibody response.大鼠中亲同种细胞抗体形成的调节。8. 一种调节抗半抗原亲同种细胞抗体应答的抗原特异性T细胞因子。
J Immunol. 1973 Sep;111(3):952-61.