Teirstein P S, Goldman A I, O'Brien P J
Invest Ophthalmol Vis Sci. 1980 Nov;19(11):1268-73.
Rats entrained to a 7 A.M.:7 P.M. lighting cycle had one eye patched and then were placed in either constant light or in a 2 A.M.:2 P.M. lighting cycle. In both cases, the patched eyes maintained the original pattern of rod outer segment (ROS) disc shedding, whereas the open eyes responded to the ambient lighting conditions. When the optic nerves were severed at the optic chiasm, the shedding rhythm persisted, but it was no longer possible to shift the rhythm to a new lighting cycle. From these experiments we conclude that ROS disc shedding is regulated both by local oscillators within the orbit as well as by central elements.
将大鼠置于上午7点至晚上7点的光照周期中，遮住一只眼睛，然后将其置于持续光照环境或凌晨2点至下午2点的光照周期中。在这两种情况下，被遮住的眼睛保持视杆细胞外段（ROS）盘膜脱落的原始模式，而未遮住的眼睛则对周围光照条件作出反应。当在视交叉处切断视神经时，盘膜脱落节律仍持续存在，但不再能够将节律转变为新的光照周期。从这些实验中我们得出结论，ROS盘膜脱落受眼眶内局部振荡器以及中枢因素的调节。
