Whipple D M, Samuelson G, Heath G E, Showalter D H
J Am Vet Med Assoc. 1980 Jun 15;176(12):1348-52.
Sulfamethazine was fed to weanling pigs at the rate of 100 g/ton of ration for 98 days to investigate the depletion rate of the drug from the plasma and edible tissues of swine. The mean plasma concentration of sulfamethazine for 21 treated pigs peaked at 10.8 ppm on day 77 of the 98-day treatment period. The concentration of sulfamethazine in kidney, liver, skeletal muscle, and subcutaneous fat was at or below 0.1 ppm within 7 days after withdrawal of medicated feed. Depletion of sulfamethazine from the tissues and plasma of the treated pigs plotted on a semilogarithmic graph. Six of seven unoccupied by the treated pigs accumulated drug residues in their kidney and liver tissues. Sulfamethazine concentrations in these tissues were at or above 0.1 ppm in 5 to 14 days.
以每吨日粮100克的剂量给断奶仔猪喂食磺胺二甲嘧啶98天，以研究该药物在猪血浆和可食用组织中的消除率。在98天的治疗期内，21头接受治疗的猪的磺胺二甲嘧啶平均血浆浓度在第77天达到峰值，为10.8 ppm。停药后7天内，肾脏、肝脏、骨骼肌和皮下脂肪中的磺胺二甲嘧啶浓度处于或低于0.1 ppm。将治疗猪组织和血浆中磺胺二甲嘧啶的消除情况绘制在半对数图上。七头未被治疗猪占用的猪中有六头在其肾脏和肝脏组织中积累了药物残留。这些组织中的磺胺二甲嘧啶浓度在5至14天内处于或高于0.1 ppm。
