Urakawa C, Nakano K, Imai R
J Antibiot (Tokyo). 1980 Aug;33(8):804-9. doi: 10.7164/antibiotics.33.804.
A facile alcoholysis of 7-methoxymitosanes and 5-methoxyindolequinone under basic conditions was discovered and a series of 7-alkoxymitosanes were synthesized from mitomycins A and B using this reaction. They showed strong antibacterial activity against various Gram-positive and Gram-negative bacteria and were potent inhibitors of cultivating HeLa S-3 cells in vitro. Among them, 7-n-propoxy-7-demethoxymitomycin A (2) showed the strongest antitumor activity against solid type Sarcoma-180 in mice.
我们发现了在碱性条件下7-甲氧基丝裂霉素和5-甲氧基吲哚醌的一种简便醇解反应，并利用该反应从丝裂霉素A和B合成了一系列7-烷氧基丝裂霉素。它们对多种革兰氏阳性菌和革兰氏阴性菌均表现出较强的抗菌活性，并且是体外培养HeLa S-3细胞的有效抑制剂。其中，7-正丙氧基-7-去甲氧基丝裂霉素A（2）对小鼠实体型肉瘤-180显示出最强的抗肿瘤活性。
