Furuhata K, Komiyama K, Ogura H, Hata T
School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Chem Pharm Bull (Tokyo). 1991 Feb;39(2):255-9. doi: 10.1248/cpb.39.255.
Two new derivatives of glycosyl mitomycin C, 7-N-[4-O-(beta-D-glucopyranosyl and alpha-sialosyl)phenyl]-9a- methoxymitosanes, were synthesized, and their structures were elucidated by analysis of the nuclear magnetic resonance spectra. Field desorption mass spectrometry was successfully used for the confirmation of these structures. The cytotoxic, antibacterial, and antitumor activities of 7-N-(4-glycosylphenyl)-9a- methoxymitosanes were also examined.
合成了糖基丝裂霉素C的两种新衍生物，即7-N-[4-O-(β-D-吡喃葡萄糖基和α-唾液酸基)苯基]-9a-甲氧基丝裂霉素烷，并通过核磁共振光谱分析对其结构进行了阐明。场解吸质谱成功用于这些结构的确认。还研究了7-N-(4-糖基苯基)-9a-甲氧基丝裂霉素烷的细胞毒性、抗菌和抗肿瘤活性。
