Microbial conversion of steffimycin and steffimycin B to 10-dihydrosteffimycin and 10-dihydrosteffimycin B.
作者信息
Wiley P F, Elrod D W, Slavicek J M, Marshall V P
出版信息
J Antibiot (Tokyo). 1980 Aug;33(8):819-23. doi: 10.7164/antibiotics.33.819.
PMID:7429984
Abstract
It has been shown that steffimycin (1) and steffmycin B (2) are reduced at the C-10 carbonyl by Actinoplanes utahensis, UC-5885 and Chaetomium sp., UC-4634, respectively. Using cell-free extracts of the latter organism, the optimum conversion time, pH, and enzyme concentration have been determined for the conversion of 2 to 4. The biochemical conversion of 2 has been found to be TPNH linked.
摘要
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