Tonak J, Weidner F
J Cancer Res Clin Oncol. 1980;96(3):303-9. doi: 10.1007/BF00408103.
Our experience has shown that an increasing depth of invasion of the primary tumor is connected with a higher incidence of regional lymph node metastases. The incidence of subsequent metastases or recurrences is compared retrospectively for two groups: (1) 175 patients with elective dissection and (2) 33 patients with excision only. All patients suffered from high-risk melanomas of clinical stage I. The frequency of subsequent metastases was 21% (N = 36) for the first group and 46% (N = 15) for the second group (p less than or equal to 0.01). The 5-year survival rate (Berkson-Gage) of patients with high-risk melanomas and secondaries is 41% for the patient group (N = 27) in which elective dissection was performed and 21% for patients with therapeutic dissection (N = 52). The results speak for the elective dissection in cases of high-risk melanomas.
我们的经验表明，原发性肿瘤浸润深度的增加与区域淋巴结转移的较高发生率相关。对两组患者的后续转移或复发发生率进行回顾性比较：（1）175例行选择性清扫术的患者和（2）33例仅行切除术的患者。所有患者均患有临床I期高危黑色素瘤。第一组的后续转移频率为21%（N = 36），第二组为46%（N = 15）（p≤0.01）。对于行选择性清扫术的高危黑色素瘤及继发转移患者组（N = 27），其5年生存率（伯克森 - 盖奇法）为41%，而行治疗性清扫术的患者（N = 52）为21%。结果表明高危黑色素瘤病例应行选择性清扫术。
