全能性小鼠畸胎瘤细胞与骨髓瘤细胞杂交体中畸胎瘤表型的表达。
Expression of the teratocarcinoma phenotype in hybrids between totipotent mouse teratocarcinoma and myeloma cells.
作者信息
Correani A, Croce C M
出版信息
J Cell Physiol. 1980 Oct;105(1):73-9. doi: 10.1002/jcp.1041050110.
PMID:7430268
Abstract
We have produced somatic cell hybrids between totipotent mouse teratocarcinoma and myeloma cells. These hybrids behave like the teratocarcinoma cell parent and express teratocarcinoma embryonal antigens. However, they also express the myeloma H-2 antigens. THe availability of these hybrids should make it possible to study the expression of already rearranged immunoglobulin genes during mouse development.
摘要
我们已经培育出了全能性小鼠畸胎瘤细胞与骨髓瘤细胞之间的体细胞杂种。这些杂种细胞表现得如同畸胎瘤细胞亲本，并表达畸胎瘤胚胎抗原。然而，它们也表达骨髓瘤H-2抗原。这些杂种细胞的存在应该能够使得在小鼠发育过程中研究已重排的免疫球蛋白基因的表达成为可能。
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