Developmental potentialities and surface antigens of mouse teratocarcinoma x lymphoid cell hybrids.

Hybrids between PCC4-aza 1 teratocarcinoma cells and either thymus cells (PcT and RPcT hybrids) or Lc lymphocytic leukemia cells (PcLc hybrids) are carcinoma cells and when injected into hosts they produce tumors which are teratocarcinomas. PcT and RPcT hybrids) or Lc lymphocytic leukemia cells (PcLc hybrids) are carcinoma cells and when injected into hosts they produce tumors which are teratocarcinomas. PcT and RPcT hybrid tumors are well differentiated and include a large variety of somatic tissues. In most PcLc tumors, neuroectoderm differentiation is predomonant. Like the PCC4 parental cells, PcT, RPcT, and PcLc hybrids carry F9 embryonic antigens and do not express perceptible amounts of H-2 alloantigens. Nonexpression of the H-2d haplotype of the thymus cell parent in PcT hybrids is not due to the loss of chromosome 17 which carried the major histocompatibility complex.