Hildebrand H F, Krivosic I, Grandier-Vazeille X, Tetaert D, Biserte G
J Clin Pathol. 1980 Sep;33(9):823-9. doi: 10.1136/jcp.33.9.823.
Histological and ultrastructural studies have been undertaken on a perineal rhabdomyosarcoma from a newborn child. The spontaneous tumour has the typical feature of mesenchymoma. The recurrent tumour, however, displays some rhabdopoietic characteristics. The myosin of the recurrent tumour has been extracted and compared with human fetal myosin. These two myosins are identical in their synthetic filaments and their light-chain composition. Nevertheless, whereas the ATPase activity of fetal myosin can be stimulated considerably by increasing the ca2+ concentration, that of tumoral myosin remains very low. These results show that there are isoenzymes of myosins and there must be differences in the myosin heavy chains, particularly in the active sites. These findings are identical with those seen in experimental rhabdomyosarcoma.
对一名新生儿的会阴部横纹肌肉瘤进行了组织学和超微结构研究。该自发肿瘤具有间叶瘤的典型特征。然而，复发性肿瘤表现出一些横纹肌生成特征。已提取复发性肿瘤的肌球蛋白并与人类胎儿肌球蛋白进行比较。这两种肌球蛋白在其合成丝和轻链组成方面是相同的。然而，虽然胎儿肌球蛋白的ATP酶活性可通过增加钙离子浓度而显著增强，但肿瘤性肌球蛋白的ATP酶活性仍然很低。这些结果表明存在肌球蛋白同工酶，并且肌球蛋白重链必定存在差异，特别是在活性位点。这些发现与实验性横纹肌肉瘤中的发现相同。
