Weidler D J, Jallad N S, Black K L, Wagner J G
J Clin Pharmacol. 1980 Aug-Sep;20(8-9):543-51. doi: 10.1002/j.1552-4604.1980.tb02548.x.
The values of the pharmacokinetic parameters for pentobarbital were determined in 18 cats, 12 of which were subjected to acute ischemic stroke by ligation of the left middle cerebral artery (LMCA). All 18 ats received 50 mg/kg sodium pentobarbital during operation. The following three experimental groups were formed: control (sham-operated); ischemic stroke plus administration of 4 mg/kg dexamethasone; and ischemic stroke without dexamethasone administration. Ischemic stroke significantly prolonged the plasma half-life of pentobarbital, but concurrent administration of dexamethasone prevented this effect. Ischemic stroke significantly reduced the plasma clearance of pentobarbital, but dexamethasone prevented this reduction. Ischemic stroke significantly increased the area under the plasma pentobarbital concentration-time curve, but dexamethasone prevented this increase. Ischemic stroke significantly reduced the volume of distribution, but dexamethasone did not prevent this reduction. The alterations of the value of these pharmacokinetic parameters for pentobarbital by ischemic stroke and reversion to normal by dexamethasone treatment are discussed in the light of certain known circulatory changes which occur secondary to ischemic stroke and dexamethasone treatment.
在18只猫中测定了戊巴比妥的药代动力学参数值，其中12只通过结扎左大脑中动脉（LMCA）诱发急性缺血性中风。所有18只猫在手术期间均接受了50mg/kg的戊巴比妥钠。形成了以下三个实验组：对照组（假手术组）；缺血性中风加给予4mg/kg地塞米松；缺血性中风未给予地塞米松。缺血性中风显著延长了戊巴比妥的血浆半衰期，但同时给予地塞米松可防止这种作用。缺血性中风显著降低了戊巴比妥的血浆清除率，但地塞米松可防止这种降低。缺血性中风显著增加了血浆戊巴比妥浓度-时间曲线下面积，但地塞米松可防止这种增加。缺血性中风显著降低了分布容积，但地塞米松不能防止这种降低。根据缺血性中风和地塞米松治疗继发的某些已知循环变化，讨论了缺血性中风对戊巴比妥这些药代动力学参数值的改变以及地塞米松治疗使其恢复正常的情况。
