Black K L, Weidler D J, Jallad N S, Sodeman T M, Abrams G D
Stroke. 1978 May-Jun;9(3):245-9. doi: 10.1161/01.str.9.3.245.
The efficacy of pentobarbital in the delayed treatment of acute cerebral ischemia was investigated in cats. Cerebral ischemia was produced by left middle cerebral artery (LMCA) ligation. Ten cats received 50 mg/kg of pentobarbital prior to ligation; a second group of 10 cats received the same dose of pentobarbital 2 hrs after ligation, and the control group of 7 cats received no pentobarbital. Brains were removed after spontaneous or induced death and the volume infarction was determined histologically. It was found that the volume of brain infarction in the group receiving pentobarbital 2 hrs after ligation was significantly less than that of the control group, which received no pentobarbital; but the volume of infarction in the former group was significantly greater than that found in the experimental group, which received pentobarbital prior to ligation. However, the mortality after LMCA ligation was higher in the 2 experimental groups, which received pentobarbital therapy, than in the control group, which did not receive pentobarbital. An hypothesis was advanced, which speculated that secondary adrenal insufficiency and altered cardiovascular function accounted for the increased mortality after pentobarbital treatment of patients with ischemic stroke.
在猫身上研究了戊巴比妥对急性脑缺血延迟治疗的疗效。通过结扎左大脑中动脉（LMCA）造成脑缺血。10只猫在结扎前接受50mg/kg戊巴比妥；第二组10只猫在结扎后2小时接受相同剂量的戊巴比妥，7只猫的对照组未接受戊巴比妥。在自然死亡或诱导死亡后取出大脑，通过组织学方法确定梗死体积。结果发现，结扎后2小时接受戊巴比妥治疗组的脑梗死体积明显小于未接受戊巴比妥治疗的对照组；但前一组的梗死体积明显大于结扎前接受戊巴比妥治疗的实验组。然而，接受戊巴比妥治疗的两个实验组在结扎LMCA后的死亡率高于未接受戊巴比妥治疗的对照组。提出了一个假设，推测继发性肾上腺功能不全和心血管功能改变是戊巴比妥治疗缺血性中风患者后死亡率增加的原因。
