O'Sullivan B M, Eaves F W, Baxendell S A, Rowan K J
Aust Vet J. 1978 Oct;54(10):479-83. doi: 10.1111/j.1751-0813.1978.tb00293.x.
A leucoencephalomyelitis in 6 goat kids 2 to 5 months old is described. The disease was characterised by fever, ataxia, posterior paresis, circling and hyperaesthesia progressing to prostration. The neural lesion was confined to the white matter of the cerebellum and posterior brain stem in 4 kids, but in 2 others the cervical spinal cord was the main site affected. The lesion was characterised microscopically by dense perivascular cuffing with mononuclear cells, infiltration of the parenchyma with macrophages and a proliferation of glial cells and by a marked primary demyelination. In more advanced lesions, areas of the neurophil were replaced by a loose glial scar. There were associated pulmonary lesions of interstitial pneumonitis and hyperplasia of the peribronchiolar lymphoid tissue. Attempts to isolate an aetiological agent and to transmit the disease to young goat kids and lambs were unsuccessful. The disease has not been reported before in Australia but has distinct similarities to an infectious leucoencephalomyelitis of young goats which has been described in North America.
本文描述了6只2至5月龄山羊羔发生的白质脑脊髓炎。该病的特征为发热、共济失调、后肢轻瘫、转圈和感觉过敏，进而发展为虚脱。4只山羊羔的神经病变局限于小脑和后脑干白质，但另外2只的颈脊髓是主要受累部位。病变在显微镜下的特征为单核细胞围绕血管密集套袖状浸润、实质内巨噬细胞浸润、胶质细胞增生以及明显的原发性脱髓鞘。在更严重的病变中，嗜中性粒细胞区域被疏松的胶质瘢痕取代。同时伴有间质性肺炎和支气管周围淋巴组织增生的肺部病变。分离病原体并将该病传播给幼龄山羊羔和羔羊的尝试均未成功。此前澳大利亚尚未报道过该病，但它与北美描述的幼龄山羊传染性白质脑脊髓炎有明显相似之处。
