通过动态心电图监测评估老年慢性心房颤动的治疗。

Treatment of chronic atrial fibrillation in the elderly, assessed by ambulatory electrocardiographic monitoring.

作者信息

Wang R, Camm J, Ward D, Washington H, Martin A

出版信息

J Am Geriatr Soc. 1980 Dec;28(12):529-34. doi: 10.1111/j.1532-5415.1980.tb00001.x.

DOI:10.1111/j.1532-5415.1980.tb00001.x

Abstract

This study concerns 8 elderly patients with age-related chronic atrial fibrillation that required control of the ventricular response. The effects of oral administration of placebo, pindolol, verapamil, digoxin and digoxin + pindolol were assessed (each for a week) during three daily activity and sleep sessions, over a six-week period. Cardiac rhythm was monitored by taped electrocardiograms. Either digoxin or pindolol was effective, but digoxin was the best tolerated of all the drugs. A combination of pindolol and digoxin reduced the maximum ventricular rate without further depression of the minimum ventricular rate. Digoxin seems to be well tolerated in the control of atrial fibrillation in the elderly, and beta blockade may be a useful therapeutic adjunct.

摘要

本研究涉及8例患有与年龄相关的慢性心房颤动且需要控制心室反应的老年患者。在为期六周的时间里，在每日三次的活动和睡眠时段中，评估了口服安慰剂、吲哚洛尔、维拉帕米、地高辛以及地高辛+吲哚洛尔的效果（每种药物各服用一周）。通过磁带记录心电图监测心律。地高辛或吲哚洛尔均有效，但地高辛是所有药物中耐受性最佳的。吲哚洛尔与地高辛联合使用可降低最大心室率，而不会进一步降低最小心室率。在老年人心房颤动的控制中，地高辛似乎耐受性良好，β受体阻滞剂可能是一种有用的治疗辅助药物。