Shore D, Wills M R, Savory J, Wyatt R J
J Gerontol. 1980 Sep;35(5):656-62. doi: 10.1093/geronj/35.5.656.
The accumulation of aluminum in the cerebral cortex has been implicated as a factor in the pathogenesis of Alzheimer type senile dementia (SD) and in the dialysis dementia found in patients with chronic renal failure on long-term intermittent hemodialysis treatment. In animal studies, parathyroid hormone (PTH) produces increased absorption of aluminum from the gastrointestinal tract and elevations of aluminum in the cerebral cortex. It has been proposed that PTH elevations may increase tissue aluminum loads in patients with senile dementia. The present study was undertaken to investigate the status of circulating PTH in patients with SD and age/sex matched controls. No significant differences were found between these groups. Elevated PTH (when it did occur) seemed to be related to the degree of renal impairment rather than dementia. Differences in the distribution of aluminum in patients with dialysis dementia and SD are discussed.
铝在大脑皮质中的蓄积被认为是阿尔茨海默型老年痴呆症（SD）发病机制的一个因素，也是长期间歇性血液透析治疗的慢性肾衰竭患者所患透析性痴呆的发病因素。在动物研究中，甲状旁腺激素（PTH）会使胃肠道对铝的吸收增加，并使大脑皮质中的铝含量升高。有人提出，PTH升高可能会增加老年痴呆症患者的组织铝负荷。本研究旨在调查SD患者和年龄/性别匹配的对照组中循环PTH的状况。这些组之间未发现显著差异。PTH升高（如果确实出现）似乎与肾功能损害程度有关，而非与痴呆有关。文中讨论了透析性痴呆患者和SD患者铝分布的差异。
