Zapatero M D, Garcia de Jalon A, Pascual F, Calvo M L, Escanero J, Marro A
Unidad de Nutrición y Metales, Hospital Miguel Servet, Zaragoza, Spain.
Biol Trace Elem Res. 1995 Jan-Mar;47(1-3):235-40. doi: 10.1007/BF02790122.
The exact cause of Alzheimer's disease and the part played in it by aluminum is still speculative. We have studied serum aluminum in 356 healthy people, and we have observed that serum aluminum concentration is increased in aging people in relation to age. We suggest that this could be associated with an enhanced gastric permeability or by an increase in metal accumulation proportional to age. We have measured serum aluminum levels in patients with probable Alzheimer's disease, patients with other senile dementias, and age-matched group. Patients with probable Alzheimer's disease have statistically significant higher serum aluminum levels than patients with other types of senile dementias (alcoholic, vascular, multi-infart) and an age-matched control group. When we compare serum aluminum of patients with senile dementias from other causes with the age-matched control group, we do not find significant differences.
阿尔茨海默病的确切病因以及铝在其中所起的作用仍具有推测性。我们对356名健康人进行了血清铝研究，观察到血清铝浓度会随着年龄增长在老年人中升高。我们认为这可能与胃通透性增强或与年龄成正比的金属蓄积增加有关。我们测量了可能患有阿尔茨海默病的患者、患有其他老年痴呆症的患者以及年龄匹配组的血清铝水平。与其他类型的老年痴呆症（酒精性、血管性、多发性梗死性）患者及年龄匹配的对照组相比，可能患有阿尔茨海默病的患者血清铝水平在统计学上显著更高。当我们将其他病因导致的老年痴呆症患者的血清铝与年龄匹配的对照组进行比较时，未发现显著差异。
