Baden H P, Kubilus J, Argyris T S
J Invest Dermatol. 1980 Nov;75(5):383-7. doi: 10.1111/1523-1747.ep12523622.
The thick paw epidermis of the rat and the guinea pig showed a relatively increased amount of the heaviest fibrous polypeptide compared to the thinner epidermis of back and ear. The hyperplastic epidermis of mouse and rat induced by abrasion or painting with 12-0-tetra-decanoyl-phorbal-13-acetate (TPA) also revealed an increase in the heaviest polypeptide. The fibrous polypeptides of epidermis from scarred skin lacked components present in normal epidermis. Cultured epidermal cells showed a different fibrous polypeptide composition than the parent tissue which was altered when the cells were transplanted to an animal or grown on a dermal substrate in culture. Thus multiple factors such as hyperplasia, the dermis and cellular environment may modify the polypeptides synthesized by the keratinocyte.
与背部和耳部较薄的表皮相比，大鼠和豚鼠较厚的爪部表皮显示出相对增加的最重纤维状多肽量。由磨损或用12-0-十四烷酰佛波醇-13-乙酸酯（TPA）涂抹诱导的小鼠和大鼠的增生性表皮也显示出最重多肽的增加。瘢痕皮肤表皮的纤维状多肽缺乏正常表皮中存在的成分。培养的表皮细胞显示出与亲本组织不同的纤维状多肽组成，当细胞移植到动物体内或在培养中的真皮基质上生长时，这种组成会发生改变。因此，诸如增生、真皮和细胞环境等多种因素可能会改变角质形成细胞合成的多肽。
