进行性系统性硬化症（硬皮病）中的人类呼吸道鼻黏膜。一项电子显微镜研究。

Human respiratory nasal mucosa in progressive systemic sclerosis (scleroderma). An electron microscopic study.

作者信息

Talaat A M, Kamel M N, Aziz M T, Shaaban N A

出版信息

J Laryngol Otol. 1980 Jun;94(6):617-27. doi: 10.1017/s0022215100089325.

Abstract

The fine structure of the respiratory nasal mucosa in cases of systemic scleroderma was studied in 5 patients. The cilia were absent in all the sections examined, and the epithelium showed characteristic morphological details. Absence of the mucous elements in the sero-mucinous glands was noticed with evidence of increased activity of the serous units. The capillaries and small arterioles showed severe changes. Electron-dense deposits were seen within the various constituents of the nasal mucosa. It was assumed that the characteristics of the disease are dependent on individual reactivity of a genetically determined immune system stimulated by an undetermined factor.

摘要

对5例系统性硬皮病患者的呼吸道鼻黏膜精细结构进行了研究。在所有检查的切片中均未发现纤毛，上皮呈现出特征性的形态学细节。观察到浆液黏液性腺中黏液成分缺失，浆液性腺单位活动增强。毛细血管和小动脉出现严重变化。在鼻黏膜的各种成分中可见电子致密沉积物。据推测，该疾病的特征取决于由未确定因素刺激的遗传决定的免疫系统的个体反应性。