螺内酯对大鼠腹侧前列腺雄激素依赖性蛋白的影响。

Effect of spironolactone on androgen-dependent proteins in the ventral prostate of the rat.

作者信息

Carter D B, Silverberg A B, Harris S E

出版信息

J Endocrinol. 1980 Sep;86(3):471-6. doi: 10.1677/joe.0.0860471.

DOI:10.1677/joe.0.0860471

Abstract

The effect of spironolactone on five androgen-dependent proteins in the ventral prostate of the rat was investigated by two-dimensional gel electrophoresis. Spironolactone was given to intact male, castrated and androgen-stimulated castrated rats. It has been shown that spironolactone had no influence on the synthesis or accumulation of the androgen-dependent proteins in intact animals. However, spironolactone suppressed the restoration of the major androgen-dependent protein of low molecular weight in castrated rats given testosterone. The mechanism by which spironolactone exerts its anti-androgenic activity was shown to be unrelated to its capacity to inhibit the synthesis or accumulation of the five androgen-dependent proteins studied in this investigation.

摘要

通过二维凝胶电泳研究了螺内酯对大鼠腹侧前列腺中五种雄激素依赖性蛋白的影响。将螺内酯给予完整雄性大鼠、去势大鼠和雄激素刺激的去势大鼠。结果表明，螺内酯对完整动物体内雄激素依赖性蛋白的合成或积累没有影响。然而，螺内酯抑制了给予睾酮的去势大鼠中主要低分子量雄激素依赖性蛋白的恢复。研究表明，螺内酯发挥其抗雄激素活性的机制与其抑制本研究中所研究的五种雄激素依赖性蛋白的合成或积累的能力无关。