δ-9-四氢大麻酚对成年去势大鼠的抗雄激素作用。
Antiandrogenic effect of delta-9-tetrahydrocannabinol in adult castrated rats.
作者信息
Ghosh S P, Chatterjee T K, Ghosh J J
出版信息
J Reprod Fertil. 1981 Jul;62(2):513-7. doi: 10.1530/jrf.0.0620513.
PMID:6166747
Abstract
In ventral prostate tissues of adult castrated rats, delta-9-tetrahydrocannabinol (THC) at 10 mg/kg for 7 days counteracted the testosterone-induced changes of (i) DNA, RNA and protein content, (ii) the tartrate-insensitive form of acid phosphatase, and (iii) the isoenzyme variant of acid phosphatase associated with the secretory type enzyme. These results indicate that THC acts anti-androgenically and directly at the level of male accessory sex organs.
摘要
在成年去势大鼠的腹侧前列腺组织中，10毫克/千克的δ-9-四氢大麻酚（THC）连续给药7天，抵消了睾酮诱导的以下变化：（i）DNA、RNA和蛋白质含量；（ii）酒石酸不敏感型酸性磷酸酶；（iii）与分泌型酶相关的酸性磷酸酶同工酶变体。这些结果表明，THC具有抗雄激素作用，且直接作用于雄性附属生殖器官水平。
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