Hillman H
Med Hypotheses. 1980 Mar;6(3):233-44. doi: 10.1016/0306-9877(80)90121-8.
It has been previously shown that the endoplasmic reticulum, the Golgi apparatus, the lysosomes, the nuclear pores, and the cristae of the mitochondria could not exist in living cells. Therefore, study of them in all life sciences, or any apparent correlation between their 'structure' and 'function' should be abandoned. The consequences to biological and medical research of such conclusions are considered. Semantic and logical analyses of experiments should always be done, and all the assumptions inherent in them should be identified and tested. Research should be more directed to studies on whole living animals, rather than to metal deposits, precipitation patterns, homogenates, or tissue fixed or subjected to other powerful physical and chemical agents known to change them drastically.
先前已经表明，内质网、高尔基体、溶酶体、核孔和线粒体嵴在活细胞中不可能存在。因此，在所有生命科学中对它们的研究，或者它们“结构”与“功能”之间的任何明显关联都应摒弃。文中考虑了这些结论对生物学和医学研究的影响。应始终对实验进行语义和逻辑分析，并识别和检验其中固有的所有假设。研究应更多地针对对完整活体动物的研究，而不是金属沉积物、沉淀模式、匀浆或经固定或遭受其他已知会使其发生剧烈变化的强大物理和化学试剂处理过的组织。
