“脂质颗粒”代表膜间附着位点吗？

Do 'lipidic particles' represent intermembrane attachment sites?

作者信息

Miller R G

出版信息

Nature. 1980 Sep 11;287(5778):166-7. doi: 10.1038/287166a0.

Abstract

Although freeze-fracture electron microscopy is normally analysed with the presumption that particles represent proteins embedded within the membrane, particles which appeared to represent inverted lipid micelles within membranes have been reported. I have now confirmed the occurrence of particles in protein-free liposomes, but have found that they behave like intermembrane attachment sites rather than structures within a membrane.

摘要

尽管冷冻断裂电子显微镜分析通常是在假定颗粒代表嵌入膜内的蛋白质的前提下进行的，但已有报道称，膜内似乎代表倒置脂质微团的颗粒也存在。我现已证实在无蛋白质脂质体中存在颗粒，但发现它们的行为更像是膜间附着位点，而非膜内结构。