Index of permeability of large arteries to labeled albumin after administration of prostaglandin E2.

Prostaglandin (PG)E2 tends to increase the permeability to labeled albumin of the arterial walls of rabbits. The blood pressure decreases after administration of PGE2. The increase in permeability is probably due to direct effects of prostaglandin upon the endothelium, perhaps to an increase of cytopempsis or formation of leaks in the integrity of the cell layer.