Anandam N, Felegi W, Stern J M
Pharmacol Biochem Behav. 1980 Oct;13(4):531-5. doi: 10.1016/0091-3057(80)90276-2.
The behavioral teratogenicity of ethanol was studied in a laboratory model of the fetal alcohol syndrome. Pregnant rats were placed in one of three groups: Ethanol (4 g ethanol/kg intubated twice daily; Purina Chow ad lib.); Sucrose (7 g sucrose/kg intubated instead of ethanol; Untreated (no intubations; Purina Chow ad lib.). Ethanol offspring did not differ from either control group in neonatal body weight or developmental measures. On Day 35, 2 female offspring per litter were tested for reactivity to acoustic startle stimuli. Activity was measured during the pre-stimulus foreperiod and during inter-stimulus intervals. Ethanol pups displayed heightened startle reactivity in the absence of hyperactivity or disrupted habituation. These data indicate that ethanol in utero produces hyperreactivity in the absence of morphological, body weight or developmental abberations.
在胎儿酒精综合征的实验室模型中研究了乙醇的行为致畸性。将怀孕大鼠分为三组：乙醇组（每天两次插管给予4 g乙醇/千克；随意进食普瑞纳饲料）；蔗糖组（用7 g蔗糖/千克插管代替乙醇；未处理组（不插管；随意进食普瑞纳饲料）。乙醇组后代在新生儿体重或发育指标方面与两个对照组均无差异。在第35天，每窝选取2只雌性后代测试对听觉惊吓刺激的反应性。在刺激前的预备期和刺激间隔期测量活动情况。乙醇组幼崽在没有多动或习惯化破坏的情况下表现出增强的惊吓反应性。这些数据表明，子宫内的乙醇在没有形态、体重或发育异常的情况下会产生反应过度。
